Drug interactions
Celecoxib + Nefazodone
Severity: Moderate
Celecoxib and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity that can impair platelet function, and with an NSAID the risk of gastrointestinal bleeding increases. Nefazodone may also modestly raise celecoxib levels through CYP3A4 inhibition.
What this interaction means in plain words
Celecoxib and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction from reduced platelet serotonin plus NSAID mucosal injury.
What to do
Monitor for gastrointestinal bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective celecoxib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Nefazodone?
MediHelp rates the interaction as moderate. Celecoxib and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity that can impair platelet function, and with an NSAID the risk of gastrointestinal bleeding increases. Nefazodone may also modestly raise celecoxib levels through CYP3A4 inhibition.
How serious is the interaction between Celecoxib and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective celecoxib dose.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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