Drug interactions
Celecoxib + Olmesartan
Severity: Moderate
Celecoxib and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib can blunt the blood pressure lowering effect of olmesartan. In patients who are elderly, volume depleted or have existing renal impairment, the combination may also worsen kidney function and raise serum potassium.
What this interaction means in plain words
Celecoxib and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Olmesartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, opposing angiotensin receptor blockade and impairing glomerular filtration.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or changing the combination, and keep patients well hydrated. Use the lowest effective celecoxib dose for the shortest time or choose a non-NSAID analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Celecoxib with Olmesartan?
MediHelp rates the interaction as moderate. Celecoxib and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib can blunt the blood pressure lowering effect of olmesartan. In patients who are elderly, volume depleted or have existing renal impairment, the combination may also worsen kidney function and raise serum potassium.
How serious is the interaction between Celecoxib and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or changing the combination, and keep patients well hydrated. Use the lowest effective celecoxib dose for the shortest time or choose a non-NSAID analgesic in high-risk patients.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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