Drug interactions
Celecoxib + Paclitaxel protein bound
Severity: Minor
Celecoxib and Paclitaxel protein bound: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized mainly by CYP2C8 and to a lesser extent CYP3A4, and celecoxib is not a clinically important CYP2C8 inhibitor. A meaningful pharmacokinetic interaction is unlikely, though NSAIDs add bleeding risk in thrombocytopenic patients.
What this interaction means in plain words
Celecoxib and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak or no CYP2C8 inhibition by celecoxib; pharmacodynamic platelet effects are the main concern.
What to do
Monitor platelet counts and bleeding during chemotherapy, and avoid celecoxib if severe thrombocytopenia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celecoxib and Paclitaxel protein bound, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Paclitaxel protein bound?
MediHelp rates the interaction as minor. Celecoxib and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel is metabolized mainly by CYP2C8 and to a lesser extent CYP3A4, and celecoxib is not a clinically important CYP2C8 inhibitor. A meaningful pharmacokinetic interaction is unlikely, though NSAIDs add bleeding risk in thrombocytopenic patients.
How serious is the interaction between Celecoxib and Paclitaxel protein bound?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and bleeding during chemotherapy, and avoid celecoxib if severe thrombocytopenia develops.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
