Drug interactions
Celecoxib + Perindopril
Severity: Moderate
Celecoxib and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib can blunt the blood pressure lowering effect of perindopril. In patients who are elderly, volume-depleted or have renal impairment, the combination may cause acute kidney injury, usually reversible, and hyperkalemia.
What this interaction means in plain words
Celecoxib and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Perindopril belongs to Cardiovascular.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis by the NSAID opposes ACE inhibitor effects and reduces glomerular perfusion.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or changing therapy, and ensure adequate hydration. Use the lowest effective celecoxib dose for the shortest time, or choose an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celecoxib and Perindopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Celecoxib with Perindopril?
MediHelp rates the interaction as moderate. Celecoxib and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib can blunt the blood pressure lowering effect of perindopril. In patients who are elderly, volume-depleted or have renal impairment, the combination may cause acute kidney injury, usually reversible, and hyperkalemia.
How serious is the interaction between Celecoxib and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or changing therapy, and ensure adequate hydration. Use the lowest effective celecoxib dose for the shortest time, or choose an alternative analgesic in high-risk patients.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
