Drug interactions
Celecoxib + Phenindione
Severity: Major
Celecoxib and Phenindione: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is a vitamin K antagonist, and NSAIDs raise bleeding risk with oral anticoagulants through gastric mucosal injury and platelet effects. Celecoxib may also modestly affect anticoagulant response.
What this interaction means in plain words
Celecoxib and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive bleeding risk from vitamin K antagonism and NSAID gastrointestinal and platelet effects.
What to do
Avoid if possible and use paracetamol instead. If combined, monitor INR closely and watch for bleeding, with gastroprotection for high-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Phenindione?
MediHelp rates the interaction as major. Celecoxib and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is a vitamin K antagonist, and NSAIDs raise bleeding risk with oral anticoagulants through gastric mucosal injury and platelet effects. Celecoxib may also modestly affect anticoagulant response.
How serious is the interaction between Celecoxib and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use paracetamol instead. If combined, monitor INR closely and watch for bleeding, with gastroprotection for high-risk patients.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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