Drug interactions
Celecoxib + Promazine
Severity: Minor
Celecoxib and Promazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may modestly increase promazine exposure because promazine is partly cleared by CYP2D6. This could enhance sedation, hypotension or anticholinergic effects.
What this interaction means in plain words
Celecoxib and Promazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Celecoxib weakly inhibits CYP2D6, reducing promazine metabolism.
What to do
Monitor for increased sedation or orthostatic hypotension and reduce the promazine dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Promazine?
MediHelp rates the interaction as minor. Celecoxib and Promazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib may modestly increase promazine exposure because promazine is partly cleared by CYP2D6. This could enhance sedation, hypotension or anticholinergic effects.
How serious is the interaction between Celecoxib and Promazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or orthostatic hypotension and reduce the promazine dose if these occur.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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