Drug interactions
Celecoxib + Reteplase
Severity: Moderate
Celecoxib and Reteplase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase dissolves fibrin clots, while celecoxib can modestly impair platelet-related haemostasis and irritate the gastric mucosa. Used together, the chance of bleeding, particularly gastrointestinal bleeding, may rise.
What this interaction means in plain words
Celecoxib and Reteplase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on haemostasis: pharmacologic fibrinolysis combined with NSAID-related mucosal injury and platelet effects.
What to do
Monitor for signs of bleeding and check haemoglobin when a thrombolytic is given to a patient taking celecoxib. Consider holding the NSAID during the acute period if clinically feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Reteplase?
MediHelp rates the interaction as moderate. Celecoxib and Reteplase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reteplase dissolves fibrin clots, while celecoxib can modestly impair platelet-related haemostasis and irritate the gastric mucosa. Used together, the chance of bleeding, particularly gastrointestinal bleeding, may rise.
How serious is the interaction between Celecoxib and Reteplase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check haemoglobin when a thrombolytic is given to a patient taking celecoxib. Consider holding the NSAID during the acute period if clinically feasible.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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