Drug interactions
Celecoxib + Rivastigmine
Severity: Moderate
Celecoxib and Rivastigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholinesterase inhibitors increase gastric acid secretion and may raise the risk of ulcers and gastrointestinal bleeding, which NSAIDs also cause. The combination may therefore increase GI risk in older patients.
What this interaction means in plain words
Celecoxib and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Rivastigmine belongs to Central Nervous System.
Why it happens
Cholinergic stimulation of gastric acid secretion adds to NSAID-related mucosal injury.
What to do
Monitor for dyspepsia, melena or anemia and consider a proton pump inhibitor in patients at high GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Rivastigmine
Frequently asked questions
Can I take Celecoxib with Rivastigmine?
MediHelp rates the interaction as moderate. Celecoxib and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholinesterase inhibitors increase gastric acid secretion and may raise the risk of ulcers and gastrointestinal bleeding, which NSAIDs also cause. The combination may therefore increase GI risk in older patients.
How serious is the interaction between Celecoxib and Rivastigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dyspepsia, melena or anemia and consider a proton pump inhibitor in patients at high GI risk.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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