Drug interactions
Celecoxib + Sacubitril / valsartan
Severity: Moderate
Celecoxib and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as celecoxib can reduce renal function in patients taking sacubitril/valsartan, especially the elderly, volume-depleted or those with existing kidney impairment. They can also blunt the blood pressure lowering effect and promote hyperkalaemia and fluid retention.
What this interaction means in plain words
Celecoxib and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces glomerular perfusion, which combines with angiotensin receptor blockade to impair renal function and potassium excretion.
What to do
Monitor serum creatinine, potassium and blood pressure after starting or changing the NSAID. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Celecoxib and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as celecoxib can reduce renal function in patients taking sacubitril/valsartan, especially the elderly, volume-depleted or those with existing kidney impairment. They can also blunt the blood pressure lowering effect and promote hyperkalaemia and fluid retention.
How serious is the interaction between Celecoxib and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and blood pressure after starting or changing the NSAID. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic in high-risk patients.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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