Drug interactions
Celecoxib + Salicylates
Severity: Moderate
Celecoxib and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining celecoxib with a non-acetylated salicylate adds two drugs that can injure the gastrointestinal mucosa and impair renal function. The risk of bleeding, kidney injury and hyperkalaemia may be increased without any therapeutic gain.
What this interaction means in plain words
Celecoxib and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of prostaglandin synthesis, affecting gastric protection, platelet function and renal perfusion.
What to do
Avoid routine duplication of NSAID-type therapy. If both are necessary, monitor for gastrointestinal bleeding and check renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Salicylates?
MediHelp rates the interaction as moderate. Celecoxib and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining celecoxib with a non-acetylated salicylate adds two drugs that can injure the gastrointestinal mucosa and impair renal function. The risk of bleeding, kidney injury and hyperkalaemia may be increased without any therapeutic gain.
How serious is the interaction between Celecoxib and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of NSAID-type therapy. If both are necessary, monitor for gastrointestinal bleeding and check renal function and potassium.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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