Drug interactions
Celecoxib + Salsalate
Severity: Moderate
Celecoxib and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate prodrug with NSAID-like effects, so adding it to celecoxib duplicates therapy. The gastrointestinal bleeding, renal and potassium-related risks of NSAIDs may be greater with the combination.
What this interaction means in plain words
Celecoxib and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prostaglandin synthesis inhibition affecting gastric mucosa, platelet function and renal blood flow.
What to do
Avoid using both together where possible. If combined, monitor for gastrointestinal bleeding and check renal function and serum potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Salsalate?
MediHelp rates the interaction as moderate. Celecoxib and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate prodrug with NSAID-like effects, so adding it to celecoxib duplicates therapy. The gastrointestinal bleeding, renal and potassium-related risks of NSAIDs may be greater with the combination.
How serious is the interaction between Celecoxib and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together where possible. If combined, monitor for gastrointestinal bleeding and check renal function and serum potassium.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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