Drug interactions
Celecoxib + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Celecoxib and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs such as celecoxib reduce renal blood flow. Together they may increase the risk of acute kidney injury, particularly in dehydrated or elderly patients.
What this interaction means in plain words
Celecoxib and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion and electrolyte disturbance from the laxative combine with NSAID-induced loss of prostaglandin-mediated renal perfusion.
What to do
Consider withholding celecoxib on the day of bowel preparation and ensure adequate hydration. Monitor renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Celecoxib and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs such as celecoxib reduce renal blood flow. Together they may increase the risk of acute kidney injury, particularly in dehydrated or elderly patients.
How serious is the interaction between Celecoxib and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding celecoxib on the day of bowel preparation and ensure adequate hydration. Monitor renal function in high-risk patients.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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