Drug interactions
Celecoxib + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Celecoxib and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This bowel preparation can produce fluid and electrolyte disturbances, and celecoxib can worsen renal perfusion. The combination may increase the likelihood of kidney injury and electrolyte-related events such as arrhythmias or seizures.
What this interaction means in plain words
Celecoxib and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Preparation-induced volume depletion and electrolyte shifts are compounded by NSAID inhibition of renal prostaglandins.
What to do
Consider holding celecoxib around the bowel preparation and encourage hydration. Check renal function and electrolytes in patients at risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Celecoxib and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This bowel preparation can produce fluid and electrolyte disturbances, and celecoxib can worsen renal perfusion. The combination may increase the likelihood of kidney injury and electrolyte-related events such as arrhythmias or seizures.
How serious is the interaction between Celecoxib and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding celecoxib around the bowel preparation and encourage hydration. Check renal function and electrolytes in patients at risk.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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