Drug interactions
Celecoxib + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Celecoxib and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations can cause fluid shifts and electrolyte disturbances, and NSAIDs can promote water retention, hyponatraemia and reduced renal perfusion. The combination may increase the risk of kidney injury and electrolyte imbalance.
What this interaction means in plain words
Celecoxib and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Preparation-induced fluid and electrolyte changes combine with NSAID-mediated renal prostaglandin inhibition and effects on water handling.
What to do
Hold celecoxib during bowel preparation where feasible and ensure adequate hydration. Monitor sodium and renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Celecoxib and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations can cause fluid shifts and electrolyte disturbances, and NSAIDs can promote water retention, hyponatraemia and reduced renal perfusion. The combination may increase the risk of kidney injury and electrolyte imbalance.
How serious is the interaction between Celecoxib and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold celecoxib during bowel preparation where feasible and ensure adequate hydration. Monitor sodium and renal function in high-risk patients.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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