Drug interactions
Celecoxib + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Celecoxib and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This osmotic bowel preparation can cause dehydration and electrolyte abnormalities, while celecoxib can impair renal perfusion. Together they may increase the risk of acute kidney injury and electrolyte-related complications.
What this interaction means in plain words
Celecoxib and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume and electrolyte depletion from the preparation is worsened by NSAID inhibition of renal prostaglandins.
What to do
Consider withholding celecoxib during the preparation and keep the patient well hydrated. Check renal function and electrolytes if risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Celecoxib and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This osmotic bowel preparation can cause dehydration and electrolyte abnormalities, while celecoxib can impair renal perfusion. Together they may increase the risk of acute kidney injury and electrolyte-related complications.
How serious is the interaction between Celecoxib and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding celecoxib during the preparation and keep the patient well hydrated. Check renal function and electrolytes if risk factors exist.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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