Drug interactions
Celecoxib + Sulfamethoxazole
Severity: Moderate
Celecoxib and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole inhibits CYP2C9 and may increase celecoxib exposure, increasing the risk of NSAID adverse effects such as GI bleeding, renal impairment or fluid retention. Both drugs can also affect renal function and potassium.
What this interaction means in plain words
Celecoxib and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfamethoxazole inhibits CYP2C9, the main enzyme metabolizing celecoxib.
What to do
Monitor renal function, potassium and signs of NSAID toxicity, and use the lowest effective celecoxib dose during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Celecoxib and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole inhibits CYP2C9 and may increase celecoxib exposure, increasing the risk of NSAID adverse effects such as GI bleeding, renal impairment or fluid retention. Both drugs can also affect renal function and potassium.
How serious is the interaction between Celecoxib and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, potassium and signs of NSAID toxicity, and use the lowest effective celecoxib dose during co-therapy.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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