Drug interactions
Celecoxib + Sulfasalazine
Severity: Minor
Celecoxib and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause gastrointestinal and renal adverse effects, and sulfasalazine rarely causes blood dyscrasias that could add to bleeding concerns. Celecoxib is also a sulfonamide, which matters in patients with sulfonamide hypersensitivity.
What this interaction means in plain words
Celecoxib and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Overlapping adverse effect profiles rather than a defined pharmacokinetic interaction; NSAID prostaglandin inhibition affects renal function and potassium.
What to do
Monitor for gastrointestinal symptoms and check blood counts and renal function periodically. Do not use celecoxib in patients with a history of severe sulfonamide reactions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Sulfasalazine?
MediHelp rates the interaction as minor. Celecoxib and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause gastrointestinal and renal adverse effects, and sulfasalazine rarely causes blood dyscrasias that could add to bleeding concerns. Celecoxib is also a sulfonamide, which matters in patients with sulfonamide hypersensitivity.
How serious is the interaction between Celecoxib and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal symptoms and check blood counts and renal function periodically. Do not use celecoxib in patients with a history of severe sulfonamide reactions.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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