Drug interactions
Celecoxib + Tobramycin inhaled
Severity: Minor
Celecoxib and Tobramycin inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption of inhaled tobramycin is low, but some exposure occurs, particularly with renal impairment. NSAIDs can reduce renal function and so theoretically increase aminoglycoside accumulation and toxicity.
What this interaction means in plain words
Celecoxib and Tobramycin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive nephrotoxic potential from NSAID-related reduced renal perfusion and aminoglycoside tubular toxicity.
What to do
Monitor renal function and serum tobramycin concentration in patients with renal impairment or prolonged therapy. No action is usually needed in patients with normal kidney function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Tobramycin inhaled?
MediHelp rates the interaction as minor. Celecoxib and Tobramycin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic absorption of inhaled tobramycin is low, but some exposure occurs, particularly with renal impairment. NSAIDs can reduce renal function and so theoretically increase aminoglycoside accumulation and toxicity.
How serious is the interaction between Celecoxib and Tobramycin inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and serum tobramycin concentration in patients with renal impairment or prolonged therapy. No action is usually needed in patients with normal kidney function.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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