Drug interactions
Celecoxib + Tropisetron
Severity: Minor
Celecoxib and Tropisetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may slightly increase tropisetron exposure because tropisetron is metabolized by CYP2D6. Clinical consequences are probably minor, such as headache or constipation.
What this interaction means in plain words
Celecoxib and Tropisetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Celecoxib weakly inhibits CYP2D6, reducing tropisetron metabolism.
What to do
No routine adjustment is needed; monitor for tropisetron adverse effects, especially in CYP2D6 poor metabolizers.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Tropisetron?
MediHelp rates the interaction as minor. Celecoxib and Tropisetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib may slightly increase tropisetron exposure because tropisetron is metabolized by CYP2D6. Clinical consequences are probably minor, such as headache or constipation.
How serious is the interaction between Celecoxib and Tropisetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for tropisetron adverse effects, especially in CYP2D6 poor metabolizers.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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