Drug interactions
Celecoxib + Venlafaxine
Severity: Moderate
Celecoxib and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine reduces platelet serotonin content and aggregation, and combined with an NSAID this increases the likelihood of bleeding, especially from the upper gastrointestinal tract.
What this interaction means in plain words
Celecoxib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive effects on hemostasis from serotonin reuptake inhibition in platelets and celecoxib-related COX-2 inhibition with mucosal injury.
What to do
Monitor for bleeding and anemia, and use the lowest effective celecoxib dose for the shortest time. Add gastroprotection in older patients or those with prior GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Celecoxib with Venlafaxine?
MediHelp rates the interaction as moderate. Celecoxib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine reduces platelet serotonin content and aggregation, and combined with an NSAID this increases the likelihood of bleeding, especially from the upper gastrointestinal tract.
How serious is the interaction between Celecoxib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and anemia, and use the lowest effective celecoxib dose for the shortest time. Add gastroprotection in older patients or those with prior GI bleeding.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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