Drug interactions
Celecoxib + Vorapaxar
Severity: Major
Celecoxib and Vorapaxar: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar strongly inhibits platelet aggregation and bleeding risk rises with other agents that affect haemostasis. Celecoxib adds gastrointestinal mucosal injury and some platelet effects, which may increase bleeding.
What this interaction means in plain words
Celecoxib and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Vorapaxar blocks PAR-1 platelet receptors, producing additive bleeding risk with NSAID-related mucosal damage and platelet effects.
What to do
Avoid regular NSAID use where possible and choose an alternative analgesic. If used, monitor closely for bleeding and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Vorapaxar?
MediHelp rates the interaction as major. Celecoxib and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar strongly inhibits platelet aggregation and bleeding risk rises with other agents that affect haemostasis. Celecoxib adds gastrointestinal mucosal injury and some platelet effects, which may increase bleeding.
How serious is the interaction between Celecoxib and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and choose an alternative analgesic. If used, monitor closely for bleeding and consider gastroprotection.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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