Drug interactions
Celiprolol + Diclofenac
Severity: Moderate
Celiprolol and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac may weaken the blood pressure lowering effect of celiprolol, particularly with sustained NSAID use. Renal function may also be affected in susceptible patients.
What this interaction means in plain words
Celiprolol and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and fluid retention and vasoconstriction, opposing the beta-blocker's antihypertensive effect.
What to do
Monitor blood pressure when NSAID therapy starts, changes or stops, and use the lowest effective dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Celiprolol with Diclofenac?
MediHelp rates the interaction as moderate. Celiprolol and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac may weaken the blood pressure lowering effect of celiprolol, particularly with sustained NSAID use. Renal function may also be affected in susceptible patients.
How serious is the interaction between Celiprolol and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when NSAID therapy starts, changes or stops, and use the lowest effective dose for the shortest time.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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