Drug interactions
Celiprolol + Diflunisal
Severity: Moderate
Celiprolol and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use can blunt the blood pressure lowering effect of beta-blockers such as celiprolol. Blood pressure control may deteriorate, particularly in hypertensive patients.
What this interaction means in plain words
Celiprolol and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit renal and vascular prostaglandin synthesis, causing sodium and water retention and vasoconstriction that oppose the antihypertensive effect.
What to do
Monitor blood pressure when diflunisal is started, changed or stopped in patients on celiprolol. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Celiprolol with Diflunisal?
MediHelp rates the interaction as moderate. Celiprolol and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged NSAID use can blunt the blood pressure lowering effect of beta-blockers such as celiprolol. Blood pressure control may deteriorate, particularly in hypertensive patients.
How serious is the interaction between Celiprolol and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when diflunisal is started, changed or stopped in patients on celiprolol. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic such as paracetamol.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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