Drug interactions
Celiprolol + Esmolol
Severity: Major
Celiprolol and Esmolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent beta-blockers produce additive reductions in heart rate, AV conduction and blood pressure. Esmolol's short half-life limits the duration, but hypotension and bradycardia can occur during infusion.
What this interaction means in plain words
Celiprolol and Esmolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic beta-adrenergic blockade.
What to do
Avoid the combination where possible. If esmolol is required, use lower starting doses and monitor heart rate, blood pressure and ECG continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celiprolol and Esmolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
- Epinephrine + Esmolol Major
Frequently asked questions
Can I take Celiprolol with Esmolol?
MediHelp rates the interaction as major. Celiprolol and Esmolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent beta-blockers produce additive reductions in heart rate, AV conduction and blood pressure. Esmolol's short half-life limits the duration, but hypotension and bradycardia can occur during infusion.
How serious is the interaction between Celiprolol and Esmolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If esmolol is required, use lower starting doses and monitor heart rate, blood pressure and ECG continuously.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
