Drug interactions
Celiprolol + Hydrochlorothiazide-losartan
Severity: Moderate
Celiprolol and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celiprolol adds to the blood pressure lowering of losartan and hydrochlorothiazide, which can be useful but may cause hypotension. Hydrochlorothiazide may reduce celiprolol absorption, and losartan carries fetal toxicity risk in pregnancy.
What this interaction means in plain words
Celiprolol and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive pharmacodynamic effects, with reduced oral absorption of celiprolol in the presence of hydrochlorothiazide.
What to do
Monitor blood pressure, heart rate and serum potassium when combining and adjust doses to response. Avoid in pregnancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Celiprolol with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Celiprolol and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celiprolol adds to the blood pressure lowering of losartan and hydrochlorothiazide, which can be useful but may cause hypotension. Hydrochlorothiazide may reduce celiprolol absorption, and losartan carries fetal toxicity risk in pregnancy.
How serious is the interaction between Celiprolol and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium when combining and adjust doses to response. Avoid in pregnancy.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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