Drug interactions
Celiprolol + Indomethacin
Severity: Moderate
Celiprolol and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can reduce the blood pressure lowering effect of beta-blockers such as celiprolol. Sustained NSAID use may lead to loss of blood pressure control.
What this interaction means in plain words
Celiprolol and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit vasodilatory prostaglandin synthesis and promote sodium and fluid retention, antagonizing the antihypertensive effect.
What to do
Monitor blood pressure when indomethacin is started or stopped and adjust antihypertensive therapy if needed. Prefer a non-NSAID analgesic for long-term use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Celiprolol with Indomethacin?
MediHelp rates the interaction as moderate. Celiprolol and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can reduce the blood pressure lowering effect of beta-blockers such as celiprolol. Sustained NSAID use may lead to loss of blood pressure control.
How serious is the interaction between Celiprolol and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when indomethacin is started or stopped and adjust antihypertensive therapy if needed. Prefer a non-NSAID analgesic for long-term use.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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