Drug interactions
Celiprolol + Nadolol
Severity: Major
Celiprolol and Nadolol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two beta-blockers given together produce duplicate therapy with additive bradycardia, hypotension and conduction block. Celiprolol may also reduce nadolol absorption or exposure, making effects unpredictable.
What this interaction means in plain words
Celiprolol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive beta-adrenergic blockade.
What to do
Avoid concurrent use and choose a single beta-blocker. Monitor heart rate and blood pressure during any transition.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nadolol
Frequently asked questions
Can I take Celiprolol with Nadolol?
MediHelp rates the interaction as major. Celiprolol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two beta-blockers given together produce duplicate therapy with additive bradycardia, hypotension and conduction block. Celiprolol may also reduce nadolol absorption or exposure, making effects unpredictable.
How serious is the interaction between Celiprolol and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a single beta-blocker. Monitor heart rate and blood pressure during any transition.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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