Drug interactions
Celiprolol + Phentolamine
Severity: Moderate
Celiprolol and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an alpha-blocker with a beta-blocker that has vasodilating properties can cause additive blood pressure lowering. Symptomatic hypotension or dizziness may occur.
What this interaction means in plain words
Celiprolol and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-blockade and beta-blockade with vasodilation.
What to do
Monitor blood pressure and heart rate, especially when starting or changing doses. Lower the dose of one drug if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celiprolol and Phentolamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Phentolamine
Frequently asked questions
Can I take Celiprolol with Phentolamine?
MediHelp rates the interaction as moderate. Celiprolol and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an alpha-blocker with a beta-blocker that has vasodilating properties can cause additive blood pressure lowering. Symptomatic hypotension or dizziness may occur.
How serious is the interaction between Celiprolol and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially when starting or changing doses. Lower the dose of one drug if hypotension occurs.
What other medicines interact with Phentolamine?
MediHelp also lists interactions of Phentolamine with, for example, Alfuzosin, Avanafil, Doxazosin. The full list is on the Phentolamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
