Drug interactions
Celiprolol + Sulindac
Severity: Moderate
Celiprolol and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use can reduce the blood pressure lowering effect of beta-blockers. Sulindac may be less affected than some other NSAIDs, but loss of antihypertensive control can still occur.
What this interaction means in plain words
Celiprolol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of vasodilatory renal and vascular prostaglandins with sodium and water retention, antagonising antihypertensive effect.
What to do
Monitor blood pressure when NSAID therapy is started, changed or continued beyond a week. Adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Celiprolol with Sulindac?
MediHelp rates the interaction as moderate. Celiprolol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged NSAID use can reduce the blood pressure lowering effect of beta-blockers. Sulindac may be less affected than some other NSAIDs, but loss of antihypertensive control can still occur.
How serious is the interaction between Celiprolol and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when NSAID therapy is started, changed or continued beyond a week. Adjust the antihypertensive regimen if control is lost.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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