Drug interactions
Celiprolol + Verapamil
Severity: Moderate
Celiprolol and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil with a beta-blocker such as celiprolol may produce additive bradycardia, AV conduction delay and hypotension. Celiprolol has partial agonist activity and some vasodilating properties, but the risk remains relevant in susceptible patients.
What this interaction means in plain words
Celiprolol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative chronotropic and dromotropic effects plus additive blood pressure lowering.
What to do
Monitor heart rate, ECG and blood pressure, and avoid the combination in patients with conduction disease or heart failure. Avoid intravenous verapamil.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Celiprolol with Verapamil?
MediHelp rates the interaction as moderate. Celiprolol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil with a beta-blocker such as celiprolol may produce additive bradycardia, AV conduction delay and hypotension. Celiprolol has partial agonist activity and some vasodilating properties, but the risk remains relevant in susceptible patients.
How serious is the interaction between Celiprolol and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and blood pressure, and avoid the combination in patients with conduction disease or heart failure. Avoid intravenous verapamil.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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