Drug interactions
Cenobamate + Chlordiazepoxide-clidinium
Severity: Moderate
Cenobamate and Chlordiazepoxide-clidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate causes somnolence and dizziness that may add to benzodiazepine sedation. Cenobamate may also alter benzodiazepine concentrations through effects on CYP enzymes.
What this interaction means in plain words
Cenobamate and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression, with possible pharmacokinetic effects of cenobamate on CYP enzymes.
What to do
Monitor for sedation and ataxia and adjust the benzodiazepine dose accordingly. Counsel patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as moderate. Cenobamate and Chlordiazepoxide-clidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate causes somnolence and dizziness that may add to benzodiazepine sedation. Cenobamate may also alter benzodiazepine concentrations through effects on CYP enzymes.
How serious is the interaction between Cenobamate and Chlordiazepoxide-clidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and ataxia and adjust the benzodiazepine dose accordingly. Counsel patients about driving.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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