Drug interactions
Cenobamate + Chlorzoxazone
Severity: Moderate
Cenobamate and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate commonly causes somnolence, dizziness and fatigue, and chlorzoxazone adds to these effects. The combination may impair coordination and alertness more than either drug alone.
What this interaction means in plain words
Cenobamate and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects of the two drugs.
What to do
Monitor for excessive sedation and dizziness, particularly during cenobamate titration. Reduce the chlorzoxazone dose or stop it if impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Chlorzoxazone?
MediHelp rates the interaction as moderate. Cenobamate and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate commonly causes somnolence, dizziness and fatigue, and chlorzoxazone adds to these effects. The combination may impair coordination and alertness more than either drug alone.
How serious is the interaction between Cenobamate and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and dizziness, particularly during cenobamate titration. Reduce the chlorzoxazone dose or stop it if impairment develops.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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