Drug interactions
Cenobamate + Cilostazol
Severity: Moderate
Cenobamate and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 inducer and can reduce cilostazol concentrations, possibly diminishing its efficacy. The effect on cilostazol has not been well characterized.
What this interaction means in plain words
Cenobamate and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Cilostazol belongs to Cardiovascular.
Why it happens
CYP3A4 induction by cenobamate accelerates cilostazol clearance.
What to do
Monitor claudication symptoms and consider an alternative to cilostazol if benefit is lost. Do not exceed the labeled cilostazol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Cilostazol?
MediHelp rates the interaction as moderate. Cenobamate and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate is a CYP3A4 inducer and can reduce cilostazol concentrations, possibly diminishing its efficacy. The effect on cilostazol has not been well characterized.
How serious is the interaction between Cenobamate and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor claudication symptoms and consider an alternative to cilostazol if benefit is lost. Do not exceed the labeled cilostazol dose.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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