Drug interactions
Cenobamate + Dexlansoprazole
Severity: Moderate
Cenobamate and Dexlansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and inhibits CYP2C19, so dexlansoprazole exposure may change in either direction. The net effect is uncertain but may affect acid control or tolerability.
What this interaction means in plain words
Cenobamate and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Cenobamate induces CYP3A4 and inhibits CYP2C19, which alter dexlansoprazole metabolism.
What to do
Monitor acid-related symptoms and adverse effects, and adjust the dexlansoprazole dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Dexlansoprazole?
MediHelp rates the interaction as moderate. Cenobamate and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and inhibits CYP2C19, so dexlansoprazole exposure may change in either direction. The net effect is uncertain but may affect acid control or tolerability.
How serious is the interaction between Cenobamate and Dexlansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor acid-related symptoms and adverse effects, and adjust the dexlansoprazole dose if needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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