Drug interactions
Dacomitinib + Dexlansoprazole
Severity: Major
Dacomitinib and Dexlansoprazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexlansoprazole lowers dacomitinib exposure by raising gastric pH, which may reduce its efficacy in lung cancer treatment. The legacy direction of effect is reversed.
What this interaction means in plain words
Dacomitinib and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces dacomitinib dissolution and absorption.
What to do
Avoid PPIs with dacomitinib. If acid suppression is needed, use a locally acting antacid or give dacomitinib at least 6 hours before or 10 hours after an H2 blocker.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
- Dexlansoprazole + Erlotinib Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Dexlansoprazole?
MediHelp rates the interaction as major. Dacomitinib and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dexlansoprazole lowers dacomitinib exposure by raising gastric pH, which may reduce its efficacy in lung cancer treatment. The legacy direction of effect is reversed.
How serious is the interaction between Dacomitinib and Dexlansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dacomitinib. If acid suppression is needed, use a locally acting antacid or give dacomitinib at least 6 hours before or 10 hours after an H2 blocker.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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