Drug interactions
Dasatinib + Dexlansoprazole
Severity: Major
Dasatinib and Dexlansoprazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib absorption depends on acidic gastric pH, so PPIs reduce its exposure and may compromise leukemia control.
What this interaction means in plain words
Dasatinib and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Raised gastric pH reduces dasatinib dissolution and absorption.
What to do
Avoid PPIs with dasatinib. Use a short-acting antacid at least 2 hours apart from dasatinib if acid suppression is needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dexlansoprazole + Erlotinib Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Dexlansoprazole?
MediHelp rates the interaction as major. Dasatinib and Dexlansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib absorption depends on acidic gastric pH, so PPIs reduce its exposure and may compromise leukemia control.
How serious is the interaction between Dasatinib and Dexlansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dasatinib. Use a short-acting antacid at least 2 hours apart from dasatinib if acid suppression is needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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