Drug interactions
Cenobamate + Flutamide
Severity: Minor
Cenobamate and Flutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 inducer and may reduce flutamide plasma concentrations. This could weaken the antiandrogen effect of flutamide over time.
What this interaction means in plain words
Cenobamate and Flutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cenobamate belongs to Central Nervous System; Flutamide belongs to Endocrine.
Why it happens
Cenobamate induces CYP3A4, accelerating flutamide metabolism.
What to do
Monitor PSA and clinical response to flutamide when cenobamate is started or stopped. Consider an alternative antiandrogen if response declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flutamide
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Flutamide?
MediHelp rates the interaction as minor. Cenobamate and Flutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cenobamate is a CYP3A4 inducer and may reduce flutamide plasma concentrations. This could weaken the antiandrogen effect of flutamide over time.
How serious is the interaction between Cenobamate and Flutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor PSA and clinical response to flutamide when cenobamate is started or stopped. Consider an alternative antiandrogen if response declines.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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