Drug interactions
Flutamide + Pexidartinib
Severity: Major
Flutamide and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both flutamide and pexidartinib can cause serious liver injury, and combined use may increase the risk of severe hepatotoxicity. Pexidartinib is restricted through a risk program because of cholestatic liver injury.
What this interaction means in plain words
Flutamide and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity from two hepatotoxic drugs.
What to do
Avoid combining them. If unavoidable, monitor liver tests closely and stop treatment at signs of liver injury.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flutamide
- Flutamide + Idelalisib Major
- Flutamide + Levoketoconazole Major
- Flutamide + Pretomanid Major
- Flutamide + Valoctocogene roxaparvovec Major
- Apalutamide + Flutamide Moderate
- Bupivacaine implant + Flutamide Moderate
Other interactions of Pexidartinib
Frequently asked questions
Can I take Flutamide with Pexidartinib?
MediHelp rates the interaction as major. Flutamide and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both flutamide and pexidartinib can cause serious liver injury, and combined use may increase the risk of severe hepatotoxicity. Pexidartinib is restricted through a risk program because of cholestatic liver injury.
How serious is the interaction between Flutamide and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them. If unavoidable, monitor liver tests closely and stop treatment at signs of liver injury.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pretomanid. The full list is on the Flutamide page.
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