Drug interactions
Flutamide + Levoketoconazole
Severity: Major
Flutamide and Levoketoconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may raise flutamide exposure. Both drugs carry a risk of hepatotoxicity, so combined use may increase the chance of liver injury.
What this interaction means in plain words
Flutamide and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole strongly inhibits CYP3A4, reducing flutamide metabolism, and both drugs are hepatotoxic.
What to do
Avoid the combination if possible. If used, monitor liver function tests frequently and stop at signs of liver injury.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flutamide
- Flutamide + Idelalisib Major
- Flutamide + Pexidartinib Major
- Flutamide + Pretomanid Major
- Flutamide + Valoctocogene roxaparvovec Major
- Apalutamide + Flutamide Moderate
- Bupivacaine implant + Flutamide Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Flutamide with Levoketoconazole?
MediHelp rates the interaction as major. Flutamide and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor and may raise flutamide exposure. Both drugs carry a risk of hepatotoxicity, so combined use may increase the chance of liver injury.
How serious is the interaction between Flutamide and Levoketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor liver function tests frequently and stop at signs of liver injury.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Pexidartinib, Pretomanid. The full list is on the Flutamide page.
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