Drug interactions
Cenobamate + Hydrocodone
Severity: Moderate
Cenobamate and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower hydrocodone concentrations, leading to reduced pain relief. Withdrawal of cenobamate could allow hydrocodone levels to climb and cause toxicity.
What this interaction means in plain words
Cenobamate and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Hydrocodone belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 increasing hydrocodone clearance.
What to do
Monitor analgesic response and adjust hydrocodone dose upward if needed. Reassess dose and monitor for respiratory depression when cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Hydrocodone?
MediHelp rates the interaction as moderate. Cenobamate and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower hydrocodone concentrations, leading to reduced pain relief. Withdrawal of cenobamate could allow hydrocodone levels to climb and cause toxicity.
How serious is the interaction between Cenobamate and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and adjust hydrocodone dose upward if needed. Reassess dose and monitor for respiratory depression when cenobamate is stopped.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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