Drug interactions
Cenobamate + Imatinib
Severity: Moderate
Cenobamate and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4, which can lower imatinib concentrations and reduce its efficacy. This matters in leukemia and GIST, where adequate exposure drives response.
What this interaction means in plain words
Cenobamate and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Cenobamate induces CYP3A4, increasing imatinib clearance.
What to do
Monitor response to imatinib, and consider a dose increase guided by clinical response or plasma level. Reassess the dose if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cenobamate and Imatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Imatinib?
MediHelp rates the interaction as moderate. Cenobamate and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4, which can lower imatinib concentrations and reduce its efficacy. This matters in leukemia and GIST, where adequate exposure drives response.
How serious is the interaction between Cenobamate and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to imatinib, and consider a dose increase guided by clinical response or plasma level. Reassess the dose if cenobamate is stopped.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
