Drug interactions
Cenobamate + Levetiracetam
Severity: Moderate
Cenobamate and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antiseizure medicines with somnolence, dizziness and fatigue as common adverse effects. Used together they may increase CNS adverse effects, particularly during cenobamate titration.
What this interaction means in plain words
Cenobamate and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Titrate cenobamate slowly and monitor for sedation, dizziness and ataxia. Reduce the dose of one agent if adverse effects limit tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Levetiracetam?
MediHelp rates the interaction as moderate. Cenobamate and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antiseizure medicines with somnolence, dizziness and fatigue as common adverse effects. Used together they may increase CNS adverse effects, particularly during cenobamate titration.
How serious is the interaction between Cenobamate and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate cenobamate slowly and monitor for sedation, dizziness and ataxia. Reduce the dose of one agent if adverse effects limit tolerability.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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