Drug interactions
Cenobamate + Metaxalone
Severity: Minor
Cenobamate and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and can lower plasma concentrations of drugs cleared by this enzyme. Metaxalone is partly metabolized by CYP3A4 among other enzymes, so its muscle relaxant effect may be reduced.
What this interaction means in plain words
Cenobamate and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cenobamate belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Cenobamate induction of CYP3A4 increases the metabolic clearance of metaxalone.
What to do
Watch for reduced muscle relaxant efficacy when cenobamate is started or the dose is increased. Adjust the metaxalone dose only if the response is inadequate and tolerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Metaxalone?
MediHelp rates the interaction as minor. Cenobamate and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cenobamate induces CYP3A4 and can lower plasma concentrations of drugs cleared by this enzyme. Metaxalone is partly metabolized by CYP3A4 among other enzymes, so its muscle relaxant effect may be reduced.
How serious is the interaction between Cenobamate and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for reduced muscle relaxant efficacy when cenobamate is started or the dose is increased. Adjust the metaxalone dose only if the response is inadequate and tolerated.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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