Drug interactions
Cenobamate + Mifepristone
Severity: Moderate
Cenobamate and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 inducer and may lower mifepristone concentrations. This could reduce mifepristone efficacy for its intended indication.
What this interaction means in plain words
Cenobamate and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Induction of CYP3A4 by cenobamate increases mifepristone metabolism.
What to do
Monitor clinical response to mifepristone and increase its dose if needed, within labeled limits. Reassess the dose when cenobamate is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Mifepristone?
MediHelp rates the interaction as moderate. Cenobamate and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate is a CYP3A4 inducer and may lower mifepristone concentrations. This could reduce mifepristone efficacy for its intended indication.
How serious is the interaction between Cenobamate and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to mifepristone and increase its dose if needed, within labeled limits. Reassess the dose when cenobamate is started or stopped.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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