Drug interactions
Cenobamate + Nicardipine
Severity: Moderate
Cenobamate and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and can lower nicardipine concentrations, potentially reducing blood pressure control. The effect may emerge gradually as induction develops.
What this interaction means in plain words
Cenobamate and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by cenobamate, increasing nicardipine clearance.
What to do
Monitor blood pressure after cenobamate is started or titrated and increase the nicardipine dose as needed. Reassess the dose if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Nicardipine?
MediHelp rates the interaction as moderate. Cenobamate and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and can lower nicardipine concentrations, potentially reducing blood pressure control. The effect may emerge gradually as induction develops.
How serious is the interaction between Cenobamate and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after cenobamate is started or titrated and increase the nicardipine dose as needed. Reassess the dose if cenobamate is stopped.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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