Drug interactions
Cenobamate + Quinidine
Severity: Moderate
Cenobamate and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may reduce quinidine concentrations. Antiarrhythmic effect may be lost.
What this interaction means in plain words
Cenobamate and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Cenobamate induces CYP3A4, accelerating quinidine metabolism.
What to do
Monitor ECG and quinidine levels, and increase the quinidine dose if needed. Reassess the dose when cenobamate is changed or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Quinidine?
MediHelp rates the interaction as moderate. Cenobamate and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may reduce quinidine concentrations. Antiarrhythmic effect may be lost.
How serious is the interaction between Cenobamate and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and quinidine levels, and increase the quinidine dose if needed. Reassess the dose when cenobamate is changed or stopped.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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