Drug interactions
Cenobamate + Secobarbital
Severity: Moderate
Cenobamate and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause somnolence and CNS depression, so combined use increases sedation and impaired coordination. Cenobamate also affects the metabolism of other anticonvulsants, including barbiturates.
What this interaction means in plain words
Cenobamate and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS depression; cenobamate inhibits CYP2C19 and induces CYP3A4, which may alter barbiturate exposure.
What to do
Monitor for sedation and ataxia and adjust doses as needed. Counsel patients about driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Secobarbital?
MediHelp rates the interaction as moderate. Cenobamate and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause somnolence and CNS depression, so combined use increases sedation and impaired coordination. Cenobamate also affects the metabolism of other anticonvulsants, including barbiturates.
How serious is the interaction between Cenobamate and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and ataxia and adjust doses as needed. Counsel patients about driving and machinery.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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