Drug interactions
Cenobamate + Sertraline
Severity: Moderate
Cenobamate and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate inhibits CYP2C19, which contributes to sertraline metabolism, so sertraline levels may rise. Both drugs also cause somnolence and dizziness.
What this interaction means in plain words
Cenobamate and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
CYP2C19 inhibition by cenobamate decreases sertraline clearance, with additive CNS depression.
What to do
Consider a lower sertraline dose and monitor for serotonergic effects and excess sedation. Titrate cenobamate slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cenobamate and Sertraline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Sertraline?
MediHelp rates the interaction as moderate. Cenobamate and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate inhibits CYP2C19, which contributes to sertraline metabolism, so sertraline levels may rise. Both drugs also cause somnolence and dizziness.
How serious is the interaction between Cenobamate and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower sertraline dose and monitor for serotonergic effects and excess sedation. Titrate cenobamate slowly.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
