Drug interactions
Cenobamate + Thioridazine
Severity: Moderate
Cenobamate and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate commonly causes somnolence and dizziness, and thioridazine adds sedation. Cenobamate also shortens the QT interval, but thioridazine's arrhythmia risk still applies, and cenobamate may induce metabolism of some drugs.
What this interaction means in plain words
Cenobamate and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and impaired coordination and titrate cenobamate slowly. Adjust doses if daytime impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Thioridazine?
MediHelp rates the interaction as moderate. Cenobamate and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate commonly causes somnolence and dizziness, and thioridazine adds sedation. Cenobamate also shortens the QT interval, but thioridazine's arrhythmia risk still applies, and cenobamate may induce metabolism of some drugs.
How serious is the interaction between Cenobamate and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and impaired coordination and titrate cenobamate slowly. Adjust doses if daytime impairment develops.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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