Drug interactions
Cenobamate + Ticagrelor
Severity: Major
Cenobamate and Ticagrelor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate is a CYP3A4 inducer and may lower ticagrelor and its active metabolite exposure. Reduced antiplatelet effect could raise the risk of stent thrombosis or ischemic events.
What this interaction means in plain words
Cenobamate and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cenobamate belongs to Central Nervous System; Ticagrelor belongs to Cardiovascular.
Why it happens
Cenobamate induces CYP3A4, increasing ticagrelor clearance.
What to do
Avoid the combination where possible, as strong inducers are not recommended with ticagrelor. If used, consider an alternative antiplatelet such as one not dependent on CYP3A4.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Ticagrelor?
MediHelp rates the interaction as major. Cenobamate and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cenobamate is a CYP3A4 inducer and may lower ticagrelor and its active metabolite exposure. Reduced antiplatelet effect could raise the risk of stent thrombosis or ischemic events.
How serious is the interaction between Cenobamate and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as strong inducers are not recommended with ticagrelor. If used, consider an alternative antiplatelet such as one not dependent on CYP3A4.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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